BindingDB logo
myBDB logout

BDBM50395768 CHEMBL2164498

SMILES: CN1CCN(CC(=O)NC2(C(=O)Nc3cc(Cl)c(C)cc23)c2ccc(Cl)cc2Cl)CC1

InChI Key: InChIKey=GLEPWHYXHJDCBG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50395768   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ghrelin receptor


(Homo sapiens (Human))		BDBM50395768
PNG
(CHEMBL2164498)
Show SMILES CN1CCN(CC(=O)NC2(C(=O)Nc3cc(Cl)c(C)cc23)c2ccc(Cl)cc2Cl)CC1
Show InChI InChI=1S/C22H23Cl3N4O2/c1-13-9-16-19(11-17(13)24)26-21(31)22(16,15-4-3-14(23)10-18(15)25)27-20(30)12-29-7-5-28(2)6-8-29/h3-4,9-11H,5-8,12H2,1-2H3,(H,26,31)(H,27,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi Research

Curated by ChEMBL


Assay Description
Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay

Bioorg Med Chem 20: 5623-36 (2012)


Article DOI: 10.1016/j.bmc.2012.07.018
BindingDB Entry DOI: 10.7270/Q2HD7WS4
More data for this
Ligand-Target Pair