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SMILES: CN(C)c1cccc(c1)C(=O)Nc1ccccc1-c1nc2ncccc2o1

InChI Key: InChIKey=ODNIVPPJGAHLKV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50396048   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NAD-dependent protein deacetylase sirtuin-1


(Homo sapiens (Human))		BDBM50396048
PNG
(CHEMBL483942)
Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccccc1-c1nc2ncccc2o1
Show InChI InChI=1S/C21H18N4O2/c1-25(2)15-8-5-7-14(13-15)20(26)23-17-10-4-3-9-16(17)21-24-19-18(27-21)11-6-12-22-19/h3-13H,1-2H3,(H,23,26)
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Article
PubMed
n/an/an/an/a 4.40E+3n/an/an/an/a



Sirtris, A GSK Company

Curated by ChEMBL


Assay Description
Activation of SIRT1

J Med Chem 54: 417-32 (2011)


Article DOI: 10.1021/jm100861p
BindingDB Entry DOI: 10.7270/Q25X2B28
More data for this
Ligand-Target Pair