BDBM50396327 CHEMBL2172624
SMILES: Cc1nc(N)nc(n1)-c1c(Nc2ccn(C)n2)nc2ccc(cn12)-c1cncnc1
InChI Key: InChIKey=TUWJPVMJCJKZBV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50396327 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50396327
(CHEMBL2172624)Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn(C)n2)nc2ccc(cn12)-c1cncnc1 Show InChI InChI=1S/C19H17N11/c1-11-23-17(27-19(20)24-11)16-18(25-14-5-6-29(2)28-14)26-15-4-3-12(9-30(15)16)13-7-21-10-22-8-13/h3-10H,1-2H3,(H,25,28)(H2,20,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of mTOR by LanthaScreen assay |
Bioorg Med Chem Lett 22: 4967-74 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.033 BindingDB Entry DOI: 10.7270/Q2BK1DHN |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50396327
(CHEMBL2172624)Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn(C)n2)nc2ccc(cn12)-c1cncnc1 Show InChI InChI=1S/C19H17N11/c1-11-23-17(27-19(20)24-11)16-18(25-14-5-6-29(2)28-14)26-15-4-3-12(9-30(15)16)13-7-21-10-22-8-13/h3-10H,1-2H3,(H,25,28)(H2,20,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 635 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha by AlphaScreen assay |
Bioorg Med Chem Lett 22: 4967-74 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.033 BindingDB Entry DOI: 10.7270/Q2BK1DHN |
More data for this Ligand-Target Pair | |