BDBM50397427 CHEMBL2170553

SMILES: CNC(=O)c1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1

InChI Key: InChIKey=QGBWLAVVBBEGCQ-VBIJGHLJSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50397427   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50397427 (CHEMBL2170553) Show SMILES CNC(=O)c1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C29H29NO8/c1-30-26(32)17-14-20(36-3)24-21(15-17)38-29(18-10-12-19(35-2)13-11-18)23(16-8-6-5-7-9-16)22(27(33)37-4)25(31)28(24,29)34/h5-15,22-23,25,31,34H,1-4H3,(H,30,32)/t22-,23-,25-,28+,29+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a
Infinity Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...				J Med Chem 55: 8859-78 (2012) Article DOI: 10.1021/jm3011542 BindingDB Entry DOI: 10.7270/Q23R0V1X
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50397427 (CHEMBL2170553) Show SMILES CNC(=O)c1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C29H29NO8/c1-30-26(32)17-14-20(36-3)24-21(15-17)38-29(18-10-12-19(35-2)13-11-18)23(16-8-6-5-7-9-16)22(27(33)37-4)25(31)28(24,29)34/h5-15,22-23,25,31,34H,1-4H3,(H,30,32)/t22-,23-,25-,28+,29+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Infinity Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...				J Med Chem 55: 8859-78 (2012) Article DOI: 10.1021/jm3011542 BindingDB Entry DOI: 10.7270/Q23R0V1X
					More data for this Ligand-Target Pair