BDBM50397445 CHEMBL2170715

SMILES: CO[C@@H]1OC[C@H](CCO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1

InChI Key: InChIKey=FHFGXZOISSRNIH-VOUWLVCMSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50397445   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50397445 (CHEMBL2170715) Show SMILES CO[C@@H]1OC[C@H](CCO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31+,32+,33-,34-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>200	n/a	n/a	n/a	n/a
Infinity Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...				J Med Chem 55: 8859-78 (2012) Article DOI: 10.1021/jm3011542 BindingDB Entry DOI: 10.7270/Q23R0V1X
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50397445 (CHEMBL2170715) Show SMILES CO[C@@H]1OC[C@H](CCO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31+,32+,33-,34-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.50E+3	n/a	n/a	n/a	n/a
Infinity Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...				J Med Chem 55: 8859-78 (2012) Article DOI: 10.1021/jm3011542 BindingDB Entry DOI: 10.7270/Q23R0V1X
					More data for this Ligand-Target Pair