null

SMILES: CC(C)Oc1nc(nc2CCN(Cc12)S(=O)(=O)c1cccnc1)-c1ccc(Cl)nc1

InChI Key: InChIKey=GGRRBUUAIYPJKH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50398012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398012 (CHEMBL2180422 | US8492392, 1-17) Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)S(=O)(=O)c1cccnc1)-c1ccc(Cl)nc1 Show InChI InChI=1S/C20H20ClN5O3S/c1-13(2)29-20-16-12-26(30(27,28)15-4-3-8-22-11-15)9-7-17(16)24-19(25-20)14-5-6-18(21)23-10-14/h3-6,8,10-11,13H,7,9,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PDE10A by fluorescence polarization assay				J Med Chem 55: 7299-331 (2012) Article DOI: 10.1021/jm3004976 BindingDB Entry DOI: 10.7270/Q2C24XJK
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398012 (CHEMBL2180422 | US8492392, 1-17) Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)S(=O)(=O)c1cccnc1)-c1ccc(Cl)nc1 Show InChI InChI=1S/C20H20ClN5O3S/c1-13(2)29-20-16-12-26(30(27,28)15-4-3-8-22-11-15)9-7-17(16)24-19(25-20)14-5-6-18(21)23-10-14/h3-6,8,10-11,13H,7,9,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	0.630	-12.5	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Fluorescence polarization assay: The compounds of the following examples had activity in reference assays by exhibiting the ability to inhibit the hy...				US Patent US8492392 (2013) BindingDB Entry DOI: 10.7270/Q2SN07M8
					More data for this Ligand-Target Pair