BDBM50399338 CHEMBL2177606

SMILES: OC(=O)c1ccc(cc1)-n1ncc(C(=O)NC2C3CC4CC(C3)CC2C4)c1C1CCCC1

InChI Key: InChIKey=YKRNKUQRDVITDV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50399338 (CHEMBL2177606) Show SMILES OC(=O)c1ccc(cc1)-n1ncc(C(=O)NC2C3CC4CC(C3)CC2C4)c1C1CCCC1 |TLB:15:16:18.25.19:23.21.22,25:24:22:18.19.20,THB:15:16:22:18.19.20,25:19:16.24.23:22,20:19:16:23.21.22,20:21:16:18.25.19,(33.58,-8.41,;35.11,-8.57,;35.73,-9.98,;36.01,-7.32,;35.39,-5.91,;36.3,-4.67,;37.83,-4.84,;38.45,-6.23,;37.55,-7.48,;38.73,-3.59,;38.26,-2.13,;39.5,-1.22,;40.75,-2.13,;42.22,-1.66,;42.54,-.15,;43.36,-2.69,;44.83,-2.21,;46.02,-.94,;47.35,-1.43,;48.75,-1.08,;48.76,.46,;47.36,1.03,;46.02,.56,;46.32,-.2,;46.33,-1.79,;47.73,-2.36,;40.27,-3.59,;41.18,-4.84,;40.7,-6.3,;41.94,-7.21,;43.19,-6.3,;42.71,-4.84,)| Show InChI InChI=1S/C26H31N3O3/c30-25(28-23-19-10-15-9-16(12-19)13-20(23)11-15)22-14-27-29(24(22)17-3-1-2-4-17)21-7-5-18(6-8-21)26(31)32/h5-8,14-17,19-20,23H,1-4,9-13H2,(H,28,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assay				J Med Chem 55: 10136-47 (2012) Article DOI: 10.1021/jm301252n BindingDB Entry DOI: 10.7270/Q2WM1FJT
					More data for this Ligand-Target Pair