BindingDB PrimarySearch

BDBM50399676 CHEMBL2178352::US9096601, 8-26

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1

InChI Key: InChIKey=QPOURHROVVCOHC-UHFFFAOYSA-N

Data: 45 IC50 1 Kd

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 50399676
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University US Patent					Assay Description The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...				US Patent US9096601 (2015) BindingDB Entry DOI: 10.7270/Q2NS0SNG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M) (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University US Patent					Assay Description The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...				US Patent US9096601 (2015) BindingDB Entry DOI: 10.7270/Q2NS0SNG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University US Patent					Assay Description The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...				US Patent US9096601 (2015) BindingDB Entry DOI: 10.7270/Q2NS0SNG
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Binding affinity to wild type EGFR by KINOMEscan kinase binding assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in ERK phosphorylation incubated for 8 hrs by Western blotting method				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in AKT phosphorylation incubated for 8 hrs by Western blotting method				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PKCalpha by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant EGFR by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 12 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant p38gamma by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant p38alpha by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant WNK1 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant TYK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant ROCK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PLK1 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase N2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PKN2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase N1 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PKN1 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PKCtheta by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PKBalpha by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PIM2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDK1 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant MNK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant MNK1 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 5 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant MK5 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant MK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant JNK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK3 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK1 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant IRAK4 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant GSK3beta by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant ERK2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
COUP transcription factor 1 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant COT1 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysyl-tRNA synthetase (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant SYK by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant SRC by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant MST1R by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant MET by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant KIT by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant INSR by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant IGF1R by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-4 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant ERBB4 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant ERBB2 by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant EGFR by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human recombinant ALK by radiometric kinase assay				J Med Chem 55: 10685-99 (2012) Article DOI: 10.1021/jm301365e BindingDB Entry DOI: 10.7270/Q2251KBV
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor(L858R) (Homo sapiens (Human))	BDBM50399676 (CHEMBL2178352 \| US9096601, 8-26) Show SMILES Show InChI	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University US Patent					Assay Description The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...				US Patent US9096601 (2015) BindingDB Entry DOI: 10.7270/Q2NS0SNG
					More data for this Ligand-Target Pair				3D Structure (crystal)