BDBM50399895 CHEMBL2180946

SMILES: CCCOc1ccc(cc1-c1nc(CC)c(CCC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1

InChI Key: InChIKey=HUGWFIPJELVPLM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399895   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50399895 (CHEMBL2180946) Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CCC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H34N4O4S/c1-5-8-18-20(7-3)24-22(25-23(18)28)19-16-17(9-10-21(19)31-15-6-2)32(29,30)27-13-11-26(4)12-14-27/h9-10,16H,5-8,11-15H2,1-4H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay				J Med Chem 55: 10540-50 (2012) Article DOI: 10.1021/jm301159y BindingDB Entry DOI: 10.7270/Q2154J6G
					More data for this Ligand-Target Pair