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SMILES: CCCOc1ccc(cc1-c1nc(NC(C)=O)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1

InChI Key: InChIKey=ARRPGOJVWWEDMT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399906   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50399906
PNG
(CHEMBL2180656)
Show SMILES CCCOc1ccc(cc1-c1nc(NC(C)=O)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C20H27N5O5S/c1-4-11-30-17-6-5-15(31(28,29)25-9-7-24(3)8-10-25)12-16(17)20-22-18(21-14(2)26)13-19(27)23-20/h5-6,12-13H,4,7-11H2,1-3H3,(H2,21,22,23,26,27)
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Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay

J Med Chem 55: 10540-50 (2012)


Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G
More data for this
Ligand-Target Pair