BDBM50400036 CHEMBL2177734::US9169259, I-68

SMILES: CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CO)c2)n1

InChI Key: InChIKey=RRLDDDWFZGWTPM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50400036   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50400036 (CHEMBL2177734 | US9169259, I-68) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CO)c2)n1 Show InChI InChI=1S/C23H24N6O/c1-16-5-4-11-28(16)22-9-3-8-21(26-22)25-20-14-19(27-29-12-10-24-23(20)29)18-7-2-6-17(13-18)15-30/h2-3,6-10,12-14,16,30H,4-5,11,15H2,1H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant spleen tyrosine kinase (360 to 635 amino acid residues) after 10 mins by scintillation counting analysis				J Med Chem 55: 10414-23 (2012) Article DOI: 10.1021/jm301367c BindingDB Entry DOI: 10.7270/Q2057H23
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50400036 (CHEMBL2177734 | US9169259, I-68) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CO)c2)n1 Show InChI InChI=1S/C23H24N6O/c1-16-5-4-11-28(16)22-9-3-8-21(26-22)25-20-14-19(27-29-12-10-24-23(20)29)18-7-2-6-17(13-18)15-30/h2-3,6-10,12-14,16,30H,4-5,11,15H2,1H3,(H,25,26)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.7	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair