Found 2 hits for monomerid = 50400138 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50400138
(CHEMBL2179450)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@@H]4CCOC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,16.16,TLB:0:1:7:28.3.4,8:7:6.29.1:28.3.4,8:7:4:6.1.2,THB:0:1:7.27.28:4,2:1:7:28.3.4,2:3:7:6.29.1,29:27:4:6.1.2,29:1:7.27.28:4,(34.67,-14.85,;33.13,-14.84,;32.09,-13.72,;30.67,-14.26,;30.02,-15.53,;31.05,-16.61,;32.35,-16.06,;31.06,-18.35,;29.73,-19.14,;28.39,-18.37,;28.39,-16.82,;27.06,-19.15,;25.72,-18.38,;24.39,-19.15,;24.39,-20.7,;23.05,-21.46,;21.72,-20.7,;20.31,-21.32,;19.28,-20.17,;20.05,-18.84,;21.56,-19.17,;25.73,-21.46,;27.07,-20.7,;28.4,-21.46,;28.8,-22.95,;30.29,-22.55,;29.89,-21.06,;31.86,-17.03,;30.69,-15.7,;33.28,-16.47,)| Show InChI InChI=1S/C23H32N4O3/c28-21(26-19-15-6-13-7-16(19)10-23(29,8-13)9-15)18-11-24-22(25-17-4-5-30-12-17)27-20(18)14-2-1-3-14/h11,13-17,19,29H,1-10,12H2,(H,26,28)(H,24,25,27)/t13?,15?,16?,17-,19-,23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400138
(CHEMBL2179450)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@@H]4CCOC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,16.16,TLB:0:1:7:28.3.4,8:7:6.29.1:28.3.4,8:7:4:6.1.2,THB:0:1:7.27.28:4,2:1:7:28.3.4,2:3:7:6.29.1,29:27:4:6.1.2,29:1:7.27.28:4,(34.67,-14.85,;33.13,-14.84,;32.09,-13.72,;30.67,-14.26,;30.02,-15.53,;31.05,-16.61,;32.35,-16.06,;31.06,-18.35,;29.73,-19.14,;28.39,-18.37,;28.39,-16.82,;27.06,-19.15,;25.72,-18.38,;24.39,-19.15,;24.39,-20.7,;23.05,-21.46,;21.72,-20.7,;20.31,-21.32,;19.28,-20.17,;20.05,-18.84,;21.56,-19.17,;25.73,-21.46,;27.07,-20.7,;28.4,-21.46,;28.8,-22.95,;30.29,-22.55,;29.89,-21.06,;31.86,-17.03,;30.69,-15.7,;33.28,-16.47,)| Show InChI InChI=1S/C23H32N4O3/c28-21(26-19-15-6-13-7-16(19)10-23(29,8-13)9-15)18-11-24-22(25-17-4-5-30-12-17)27-20(18)14-2-1-3-14/h11,13-17,19,29H,1-10,12H2,(H,26,28)(H,24,25,27)/t13?,15?,16?,17-,19-,23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
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