Found 2 hits for monomerid = 50400164 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400164
(CHEMBL2179029)Show SMILES CC(C)(CO)Nc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:13.12,wD:20.21,TLB:21:20:13:17.16.15,12:13:23.19.20:17.16.15,12:13:15:23.20.22,THB:21:20:13.18.17:15,22:20:13:17.16.15,22:16:13:23.19.20,19:18:15:23.20.22,19:20:13.18.17:15,(4.54,-36.94,;4.95,-38.44,;5.71,-37.1,;3.62,-39.21,;2.28,-38.44,;6.28,-39.21,;7.62,-38.44,;7.62,-36.9,;8.95,-36.13,;10.28,-36.89,;11.61,-36.12,;11.61,-34.58,;12.95,-36.88,;14.28,-36.1,;14.27,-34.36,;13.24,-33.29,;13.89,-32.01,;13.91,-33.45,;15.08,-34.78,;16.49,-34.22,;16.35,-32.59,;17.88,-32.6,;15.31,-31.47,;15.57,-33.8,;10.29,-38.44,;8.95,-39.21,;11.62,-39.21,;11.79,-40.74,;13.3,-41.05,;14.06,-39.72,;13.03,-38.58,)| Show InChI InChI=1S/C24H36N4O3/c1-23(2,13-29)28-22-25-12-18(20(27-22)15-5-3-4-6-15)21(30)26-19-16-7-14-8-17(19)11-24(31,9-14)10-16/h12,14-17,19,29,31H,3-11,13H2,1-2H3,(H,26,30)(H,25,27,28)/t14?,16?,17?,19-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50400164
(CHEMBL2179029)Show SMILES CC(C)(CO)Nc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:13.12,wD:20.21,TLB:21:20:13:17.16.15,12:13:23.19.20:17.16.15,12:13:15:23.20.22,THB:21:20:13.18.17:15,22:20:13:17.16.15,22:16:13:23.19.20,19:18:15:23.20.22,19:20:13.18.17:15,(4.54,-36.94,;4.95,-38.44,;5.71,-37.1,;3.62,-39.21,;2.28,-38.44,;6.28,-39.21,;7.62,-38.44,;7.62,-36.9,;8.95,-36.13,;10.28,-36.89,;11.61,-36.12,;11.61,-34.58,;12.95,-36.88,;14.28,-36.1,;14.27,-34.36,;13.24,-33.29,;13.89,-32.01,;13.91,-33.45,;15.08,-34.78,;16.49,-34.22,;16.35,-32.59,;17.88,-32.6,;15.31,-31.47,;15.57,-33.8,;10.29,-38.44,;8.95,-39.21,;11.62,-39.21,;11.79,-40.74,;13.3,-41.05,;14.06,-39.72,;13.03,-38.58,)| Show InChI InChI=1S/C24H36N4O3/c1-23(2,13-29)28-22-25-12-18(20(27-22)15-5-3-4-6-15)21(30)26-19-16-7-14-8-17(19)11-24(31,9-14)10-16/h12,14-17,19,29,31H,3-11,13H2,1-2H3,(H,26,30)(H,25,27,28)/t14?,16?,17?,19-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
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