BDBM50400166 CHEMBL2179027

SMILES: C[C@H](O)CNc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1

InChI Key: InChIKey=AMSDAXGEMBQOCX-WLQYVGQJSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50400166   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50400166 (CHEMBL2179027) Show SMILES C[C@H](O)CNc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:12.11,wD:19.20,1.1,TLB:20:19:12:16.15.14,11:12:22.18.19:16.15.14,11:12:14:22.19.21,THB:20:19:12.17.16:14,21:19:12:16.15.14,21:15:12:22.18.19,18:17:14:22.19.21,18:19:12.17.16:14,(40.23,-26.82,;40.24,-25.28,;38.9,-24.51,;41.57,-24.51,;42.9,-25.28,;44.24,-24.51,;44.24,-22.97,;45.57,-22.2,;46.9,-22.96,;48.24,-22.19,;48.23,-20.65,;49.57,-22.95,;50.9,-22.18,;50.89,-20.43,;49.86,-19.36,;50.51,-18.08,;50.53,-19.53,;51.7,-20.85,;53.12,-20.29,;52.97,-18.66,;54.5,-18.67,;51.93,-17.54,;52.19,-19.88,;46.91,-24.51,;45.57,-25.28,;48.24,-25.28,;48.41,-26.81,;49.92,-27.13,;50.68,-25.79,;49.65,-24.65,)| Show InChI InChI=1S/C23H34N4O3/c1-13(28)11-24-22-25-12-18(20(27-22)15-4-2-3-5-15)21(29)26-19-16-6-14-7-17(19)10-23(30,8-14)9-16/h12-17,19,28,30H,2-11H2,1H3,(H,26,29)(H,24,25,27)/t13-,14?,16?,17?,19-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 by HTRF assay				J Med Chem 55: 10652-61 (2012) Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50400166 (CHEMBL2179027) Show SMILES C[C@H](O)CNc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:12.11,wD:19.20,1.1,TLB:20:19:12:16.15.14,11:12:22.18.19:16.15.14,11:12:14:22.19.21,THB:20:19:12.17.16:14,21:19:12:16.15.14,21:15:12:22.18.19,18:17:14:22.19.21,18:19:12.17.16:14,(40.23,-26.82,;40.24,-25.28,;38.9,-24.51,;41.57,-24.51,;42.9,-25.28,;44.24,-24.51,;44.24,-22.97,;45.57,-22.2,;46.9,-22.96,;48.24,-22.19,;48.23,-20.65,;49.57,-22.95,;50.9,-22.18,;50.89,-20.43,;49.86,-19.36,;50.51,-18.08,;50.53,-19.53,;51.7,-20.85,;53.12,-20.29,;52.97,-18.66,;54.5,-18.67,;51.93,-17.54,;52.19,-19.88,;46.91,-24.51,;45.57,-25.28,;48.24,-25.28,;48.41,-26.81,;49.92,-27.13,;50.68,-25.79,;49.65,-24.65,)| Show InChI InChI=1S/C23H34N4O3/c1-13(28)11-24-22-25-12-18(20(27-22)15-4-2-3-5-15)21(29)26-19-16-6-14-7-17(19)10-23(30,8-14)9-16/h12-17,19,28,30H,2-11H2,1H3,(H,26,29)(H,24,25,27)/t13-,14?,16?,17?,19-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 by HTRF assay				J Med Chem 55: 10652-61 (2012) Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S
					More data for this Ligand-Target Pair