Found 2 hits for monomerid = 50400175 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400175
(CHEMBL2179018)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:30.3.4,8:7:6.31.1:30.3.4,8:7:4:6.1.2,THB:0:1:7.29.30:4,2:1:7:30.3.4,2:3:7:6.31.1,31:29:4:6.1.2,31:1:7.29.30:4,(33.54,-50.69,;32.01,-50.68,;30.97,-49.56,;29.55,-50.1,;28.9,-51.37,;29.93,-52.45,;31.23,-51.89,;29.94,-54.19,;28.61,-54.97,;27.27,-54.2,;27.27,-52.66,;25.94,-54.98,;24.61,-54.22,;23.28,-54.99,;23.28,-56.53,;21.94,-57.3,;20.61,-56.53,;20.62,-54.99,;19.29,-54.22,;17.95,-54.98,;17.95,-56.52,;19.28,-57.3,;24.61,-57.3,;25.95,-56.53,;27.28,-57.3,;27.45,-58.82,;28.95,-59.14,;29.72,-57.81,;28.69,-56.66,;30.74,-52.87,;29.57,-51.54,;32.15,-52.3,)| Show InChI InChI=1S/C25H36N4O3/c30-23(28-21-17-9-15-10-18(21)13-25(31,11-15)12-17)20-14-26-24(27-19-5-7-32-8-6-19)29-22(20)16-3-1-2-4-16/h14-19,21,31H,1-13H2,(H,28,30)(H,26,27,29)/t15?,17?,18?,21-,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50400175
(CHEMBL2179018)Show SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:30.3.4,8:7:6.31.1:30.3.4,8:7:4:6.1.2,THB:0:1:7.29.30:4,2:1:7:30.3.4,2:3:7:6.31.1,31:29:4:6.1.2,31:1:7.29.30:4,(33.54,-50.69,;32.01,-50.68,;30.97,-49.56,;29.55,-50.1,;28.9,-51.37,;29.93,-52.45,;31.23,-51.89,;29.94,-54.19,;28.61,-54.97,;27.27,-54.2,;27.27,-52.66,;25.94,-54.98,;24.61,-54.22,;23.28,-54.99,;23.28,-56.53,;21.94,-57.3,;20.61,-56.53,;20.62,-54.99,;19.29,-54.22,;17.95,-54.98,;17.95,-56.52,;19.28,-57.3,;24.61,-57.3,;25.95,-56.53,;27.28,-57.3,;27.45,-58.82,;28.95,-59.14,;29.72,-57.81,;28.69,-56.66,;30.74,-52.87,;29.57,-51.54,;32.15,-52.3,)| Show InChI InChI=1S/C25H36N4O3/c30-23(28-21-17-9-15-10-18(21)13-25(31,11-15)12-17)20-14-26-24(27-19-5-7-32-8-6-19)29-22(20)16-3-1-2-4-16/h14-19,21,31H,1-13H2,(H,28,30)(H,26,27,29)/t15?,17?,18?,21-,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163
BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this
Ligand-Target Pair | |
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