BDBM50400605 CHEMBL2203438

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(CC4)C4CC4)cn3)cc2)no1

InChI Key: InChIKey=BHXZFEQWQQPISU-UHFFFAOYSA-N

Data: 1 IC50  2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50400605   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse))	BDBM50400605 (CHEMBL2203438) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(CC4)C4CC4)cn3)cc2)no1 Show InChI InChI=1S/C28H34N6O4/c1-28(2,3)24-16-25(33-38-24)32-27(36)31-19-6-4-18(5-7-19)30-26(35)23-11-10-22(17-29-23)37-21-12-14-34(15-13-21)20-8-9-20/h4-7,10-11,16-17,20-21H,8-9,12-15H2,1-3H3,(H,30,35)(H2,31,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50400605 (CHEMBL2203438) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(CC4)C4CC4)cn3)cc2)no1 Show InChI InChI=1S/C28H34N6O4/c1-28(2,3)24-16-25(33-38-24)32-27(36)31-19-6-4-18(5-7-19)30-26(35)23-11-10-22(17-29-23)37-21-12-14-34(15-13-21)20-8-9-20/h4-7,10-11,16-17,20-21H,8-9,12-15H2,1-3H3,(H,30,35)(H2,31,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50400605 (CHEMBL2203438) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(CC4)C4CC4)cn3)cc2)no1 Show InChI InChI=1S/C28H34N6O4/c1-28(2,3)24-16-25(33-38-24)32-27(36)31-19-6-4-18(5-7-19)30-26(35)23-11-10-22(17-29-23)37-21-12-14-34(15-13-21)20-8-9-20/h4-7,10-11,16-17,20-21H,8-9,12-15H2,1-3H3,(H,30,35)(H2,31,32,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.28	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair