BDBM50400612 CHEMBL2203430

SMILES: Cc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1

InChI Key: InChIKey=QKFZNOQWHCBRSM-UHFFFAOYSA-N

Data: 1 IC50  2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50400612   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM50400612 (CHEMBL2203430) Show SMILES Cc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1 Show InChI InChI=1S/C21H23N5O3/c1-13-5-10-16(22-12-13)19(27)23-14-6-8-15(9-7-14)24-20(28)25-18-11-17(29-26-18)21(2,3)4/h5-12H,1-4H3,(H,23,27)(H2,24,25,26,28)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	223	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assay				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50400612 (CHEMBL2203430) Show SMILES Cc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1 Show InChI InChI=1S/C21H23N5O3/c1-13-5-10-16(22-12-13)19(27)23-14-6-8-15(9-7-14)24-20(28)25-18-11-17(29-26-18)21(2,3)4/h5-12H,1-4H3,(H,23,27)(H2,24,25,26,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to FLT3 expressed in HEK-293 cells after 1 hr				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50400612 (CHEMBL2203430) Show SMILES Cc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1 Show InChI InChI=1S/C21H23N5O3/c1-13-5-10-16(22-12-13)19(27)23-14-6-8-15(9-7-14)24-20(28)25-18-11-17(29-26-18)21(2,3)4/h5-12H,1-4H3,(H,23,27)(H2,24,25,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to CSF1R expressed in HEK-293 cells after 1 hr				ACS Med Chem Lett 3: 997-1002 (2012) Article DOI: 10.1021/ml300214g BindingDB Entry DOI: 10.7270/Q22V2H9V
					More data for this Ligand-Target Pair