BDBM50403071 CHEMBL2216887

SMILES: CC(c1nc2n(C)nc(Br)c2c(=O)n1-c1ccccc1)n1cnc2c(N)ncnc12

InChI Key: InChIKey=CPQLXZTVSCHWPG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50403071   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50403071 (CHEMBL2216887) Show SMILES CC(c1nc2n(C)nc(Br)c2c(=O)n1-c1ccccc1)n1cnc2c(N)ncnc12 Show InChI InChI=1S/C19H16BrN9O/c1-10(28-9-24-13-15(21)22-8-23-18(13)28)16-25-17-12(14(20)26-27(17)2)19(30)29(16)11-6-4-3-5-7-11/h3-10H,1-2H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	665	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in neutrophil assessed as elastase release by cell-based assay				J Med Chem 55: 8559-81 (2012) Article DOI: 10.1021/jm300847w BindingDB Entry DOI: 10.7270/Q2SN0B47
					More data for this Ligand-Target Pair