BDBM50410957 CHEMBL380239

SMILES: Cc1ccccc1Cn1nnnc1-c1cccc(Cl)c1Cl

InChI Key: InChIKey=AIXKYVDETAVYTG-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50410957   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50410957 (CHEMBL380239) Show SMILES Cc1ccccc1Cn1nnnc1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-6-11(10)9-21-15(18-19-20-21)12-7-4-8-13(16)14(12)17/h2-8H,9H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17.8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of benzoylbenzoic ATP-induced calcium product...				Bioorg Med Chem Lett 21: 3297-300 (2011) Article DOI: 10.1016/j.bmcl.2011.04.024 BindingDB Entry DOI: 10.7270/Q2FJ2J10
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM50410957 (CHEMBL380239) Show SMILES Cc1ccccc1Cn1nnnc1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-6-11(10)9-21-15(18-19-20-21)12-7-4-8-13(16)14(12)17/h2-8H,9H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69.2	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of benzoylbenzoic ATP-induced calcium productio...				Bioorg Med Chem Lett 21: 3297-300 (2011) Article DOI: 10.1016/j.bmcl.2011.04.024 BindingDB Entry DOI: 10.7270/Q2FJ2J10
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50410957 (CHEMBL380239) Show SMILES Cc1ccccc1Cn1nnnc1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-6-11(10)9-21-15(18-19-20-21)12-7-4-8-13(16)14(12)17/h2-8H,9H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptake				J Med Chem 52: 3123-41 (2009) Article DOI: 10.1021/jm801528x BindingDB Entry DOI: 10.7270/Q2251KDR
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM50410957 (CHEMBL380239) Show SMILES Cc1ccccc1Cn1nnnc1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-6-11(10)9-21-15(18-19-20-21)12-7-4-8-13(16)14(12)17/h2-8H,9H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63.1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at rat P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of calcium flux by FLIPR				J Med Chem 49: 3659-66 (2006) Article DOI: 10.1021/jm051202e BindingDB Entry DOI: 10.7270/Q2VD70P4
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50410957 (CHEMBL380239) Show SMILES Cc1ccccc1Cn1nnnc1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-6-11(10)9-21-15(18-19-20-21)12-7-4-8-13(16)14(12)17/h2-8H,9H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of calcium flux by FLIPR				J Med Chem 49: 3659-66 (2006) Article DOI: 10.1021/jm051202e BindingDB Entry DOI: 10.7270/Q2VD70P4
					More data for this Ligand-Target Pair