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SMILES: C[C@H](Nc1nccc(n1)N(C(=O)Nc1ccccc1Cl)c1ccc(F)cc1)C(C)(C)O

InChI Key: InChIKey=IMVYTDSIYAAPON-AWEZNQCLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50411064   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50411064
PNG
(CHEMBL211282)
Show SMILES C[C@H](Nc1nccc(n1)N(C(=O)Nc1ccccc1Cl)c1ccc(F)cc1)C(C)(C)O
Show InChI InChI=1S/C22H23ClFN5O2/c1-14(22(2,3)31)26-20-25-13-12-19(28-20)29(16-10-8-15(24)9-11-16)21(30)27-18-7-5-4-6-17(18)23/h4-14,31H,1-3H3,(H,27,30)(H,25,26,28)/t14-/m0/s1
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n/an/a 122n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of LPS-stimulated TNFalpha production in human THP1 cells

Bioorg Med Chem Lett 16: 3510-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.095
BindingDB Entry DOI: 10.7270/Q26Q1ZFH
More data for this
Ligand-Target Pair