BindingDB logo
myBDB logout

null

SMILES: CN1CCN(CC1)c1nccc(n1)N(C(=O)Nc1ccccc1Cl)c1ccc(F)cc1

InChI Key: InChIKey=NODKNHCIBSCIEL-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50411070   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50411070
PNG
(CHEMBL208736)
Show SMILES CN1CCN(CC1)c1nccc(n1)N(C(=O)Nc1ccccc1Cl)c1ccc(F)cc1
Show InChI InChI=1S/C22H22ClFN6O/c1-28-12-14-29(15-13-28)21-25-11-10-20(27-21)30(17-8-6-16(24)7-9-17)22(31)26-19-5-3-2-4-18(19)23/h2-11H,12-15H2,1H3,(H,26,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of LPS-stimulated TNFalpha production in human THP1 cells

Bioorg Med Chem Lett 16: 3510-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.095
BindingDB Entry DOI: 10.7270/Q26Q1ZFH
More data for this
Ligand-Target Pair