BDBM50411829 CHEMBL404237

SMILES: Cc1cn2cc(cc2c(n1)C#Cc1ccccc1)C#N

InChI Key: InChIKey=OTYYOKVURDHMBC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50411829   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50411829 (CHEMBL404237) Show SMILES Cc1cn2cc(cc2c(n1)C#Cc1ccccc1)C#N Show InChI InChI=1S/C17H11N3/c1-13-11-20-12-15(10-18)9-17(20)16(19-13)8-7-14-5-3-2-4-6-14/h2-6,9,11-12H,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human mGluR5 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR				Bioorg Med Chem Lett 18: 1804-9 (2008) Article DOI: 10.1016/j.bmcl.2008.02.024 BindingDB Entry DOI: 10.7270/Q27945W4
					More data for this Ligand-Target Pair