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SMILES: Cc1cccc(c1)C#Cc1nc(C)cn2cccc12

InChI Key: InChIKey=LRYUALJXKCLBKM-UHFFFAOYSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50411838   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50411838
PNG
(CHEMBL271276)
Show SMILES Cc1cccc(c1)C#Cc1nc(C)cn2cccc12
Show InChI InChI=1S/C17H14N2/c1-13-5-3-6-15(11-13)8-9-16-17-7-4-10-19(17)12-14(2)18-16/h3-7,10-12H,1-2H3
PDB
MMDB

KEGG

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.398n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR5 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR

Bioorg Med Chem Lett 18: 1804-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.024
BindingDB Entry DOI: 10.7270/Q27945W4
More data for this
Ligand-Target Pair