BDBM50411877 CHEMBL270678

SMILES: Cc1ccccc1Nc1ncnn1-c1cccc(Cl)c1Cl

InChI Key: InChIKey=LOVLZFNOBDCBGQ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50411877   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50411877 (CHEMBL270678) Show SMILES Cc1ccccc1Nc1ncnn1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-7-12(10)20-15-18-9-19-21(15)13-8-4-6-11(16)14(13)17/h2-9H,1H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17.8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP-induced calcium flux by FLIPR assay				Bioorg Med Chem Lett 18: 2089-92 (2008) Article DOI: 10.1016/j.bmcl.2008.01.095 BindingDB Entry DOI: 10.7270/Q2ZW1N5R
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM50411877 (CHEMBL270678) Show SMILES Cc1ccccc1Nc1ncnn1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-7-12(10)20-15-18-9-19-21(15)13-8-4-6-11(16)14(13)17/h2-9H,1H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptake				J Med Chem 52: 3123-41 (2009) Article DOI: 10.1021/jm801528x BindingDB Entry DOI: 10.7270/Q2251KDR
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50411877 (CHEMBL270678) Show SMILES Cc1ccccc1Nc1ncnn1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-7-12(10)20-15-18-9-19-21(15)13-8-4-6-11(16)14(13)17/h2-9H,1H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19.9	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptake				J Med Chem 52: 3123-41 (2009) Article DOI: 10.1021/jm801528x BindingDB Entry DOI: 10.7270/Q2251KDR
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM50411877 (CHEMBL270678) Show SMILES Cc1ccccc1Nc1ncnn1-c1cccc(Cl)c1Cl Show InChI InChI=1S/C15H12Cl2N4/c1-10-5-2-3-7-12(10)20-15-18-9-19-21(15)13-8-4-6-11(16)14(13)17/h2-9H,1H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP-induced calcium flux by FLIPR assay				Bioorg Med Chem Lett 18: 2089-92 (2008) Article DOI: 10.1016/j.bmcl.2008.01.095 BindingDB Entry DOI: 10.7270/Q2ZW1N5R
					More data for this Ligand-Target Pair