Found 4 hits for monomerid = 50411950 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
P-glycoprotein 1
(Homo sapiens (Human)) | BDBM50411950
(CHEMBL258882)Show SMILES COc1cc2CCN(CCc3ccc(NC(=O)c4cnc5ccccc5n4)cc3)Cc2cc1OC Show InChI InChI=1S/C28H28N4O3/c1-34-26-15-20-12-14-32(18-21(20)16-27(26)35-2)13-11-19-7-9-22(10-8-19)30-28(33)25-17-29-23-5-3-4-6-24(23)31-25/h3-10,15-17H,11-14,18H2,1-2H3,(H,30,33) | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 209 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Inhibition of human Pgp in A2780 cells after 30 mins by Hoechst 33342 assay |
Bioorg Med Chem 16: 2448-62 (2008)
Article DOI: 10.1016/j.bmc.2007.11.057
BindingDB Entry DOI: 10.7270/Q2QN67PT |
More data for this
Ligand-Target Pair | |
Multidrug resistance protein 1/Multidrug resistance associated protein 1
(Homo sapiens (Human)) | BDBM50411950
(CHEMBL258882)Show SMILES COc1cc2CCN(CCc3ccc(NC(=O)c4cnc5ccccc5n4)cc3)Cc2cc1OC Show InChI InChI=1S/C28H28N4O3/c1-34-26-15-20-12-14-32(18-21(20)16-27(26)35-2)13-11-19-7-9-22(10-8-19)30-28(33)25-17-29-23-5-3-4-6-24(23)31-25/h3-10,15-17H,11-14,18H2,1-2H3,(H,30,33) | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Inhibition of P-glycoprotein-mediated multidrug resistance in adriamycin-resistant human A2780/ADR cells by calcein AM assay |
Bioorg Med Chem 17: 2524-35 (2009)
Article DOI: 10.1016/j.bmc.2009.01.072
BindingDB Entry DOI: 10.7270/Q2X63QS6 |
More data for this
Ligand-Target Pair | |
ATP-binding cassette sub-family G member 2
(Homo sapiens (Human)) | BDBM50411950
(CHEMBL258882)Show SMILES COc1cc2CCN(CCc3ccc(NC(=O)c4cnc5ccccc5n4)cc3)Cc2cc1OC Show InChI InChI=1S/C28H28N4O3/c1-34-26-15-20-12-14-32(18-21(20)16-27(26)35-2)13-11-19-7-9-22(10-8-19)30-28(33)25-17-29-23-5-3-4-6-24(23)31-25/h3-10,15-17H,11-14,18H2,1-2H3,(H,30,33) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay |
Bioorg Med Chem 16: 8224-36 (2008)
Article DOI: 10.1016/j.bmc.2008.07.034
BindingDB Entry DOI: 10.7270/Q2765GK5 |
More data for this
Ligand-Target Pair | |
P-glycoprotein 1
(Homo sapiens (Human)) | BDBM50411950
(CHEMBL258882)Show SMILES COc1cc2CCN(CCc3ccc(NC(=O)c4cnc5ccccc5n4)cc3)Cc2cc1OC Show InChI InChI=1S/C28H28N4O3/c1-34-26-15-20-12-14-32(18-21(20)16-27(26)35-2)13-11-19-7-9-22(10-8-19)30-28(33)25-17-29-23-5-3-4-6-24(23)31-25/h3-10,15-17H,11-14,18H2,1-2H3,(H,30,33) | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Inhibition of human Pgp in A2780 cells after 30 mins by calcein AM assay |
Bioorg Med Chem 16: 2448-62 (2008)
Article DOI: 10.1016/j.bmc.2007.11.057
BindingDB Entry DOI: 10.7270/Q2QN67PT |
More data for this
Ligand-Target Pair | |
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