BDBM50412508 CHEMBL452925::VUF-10457

SMILES: CN1CCN(CC1)c1nc(NCc2ccco2)c2cc(Cl)ccc2n1

InChI Key: InChIKey=BKGSNELMPDFQCW-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50412508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50412508 (CHEMBL452925 | VUF-10457) Show SMILES CN1CCN(CC1)c1nc(NCc2ccco2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C18H20ClN5O/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	89.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells				J Med Chem 51: 7855-65 (2008) Article DOI: 10.1021/jm800876b BindingDB Entry DOI: 10.7270/Q29Z964R
					More data for this Ligand-Target Pair