BDBM50412815 CHEMBL457742

SMILES: COc1cc(ccc1N1CCc2c1nc(C)cc2-n1ccc(n1)-n1cc[nH]c1=O)-n1cccn1

InChI Key: InChIKey=PFNPBWMAIAIAPU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50412815   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50412815 (CHEMBL457742) Show SMILES COc1cc(ccc1N1CCc2c1nc(C)cc2-n1ccc(n1)-n1cc[nH]c1=O)-n1cccn1 Show InChI InChI=1S/C24H22N8O2/c1-16-14-20(32-12-7-22(28-32)30-13-9-25-24(30)33)18-6-11-29(23(18)27-16)19-5-4-17(15-21(19)34-2)31-10-3-8-26-31/h3-5,7-10,12-15H,6,11H2,1-2H3,(H,25,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	363	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells				J Med Chem 51: 7370-9 (2009) Article DOI: 10.1021/jm800744m BindingDB Entry DOI: 10.7270/Q2N87C1X
					More data for this Ligand-Target Pair