BDBM50413172 CHEMBL512716

SMILES: NC(NC(=O)CC(c1ccccc1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1

InChI Key: InChIKey=UEIOTBCPFPELAN-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50413172   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50413172 (CHEMBL512716) Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccc(F)c(F)c1)=NCCCc1cnc[nH]1 |w:21.23| Show InChI InChI=1S/C22H23F2N5O/c23-19-9-8-16(11-20(19)24)18(15-5-2-1-3-6-15)12-21(30)29-22(25)27-10-4-7-17-13-26-14-28-17/h1-3,5-6,8-9,11,13-14,18H,4,7,10,12H2,(H,26,28)(H3,25,27,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	53.7	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair