Found 5 hits for monomerid = 50413557 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50413557
(CHEMBL511279)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2cccc3N(CC(F)F)C(=O)COc23)CC1 Show InChI InChI=1S/C26H28F2N4O2/c1-18-8-9-20-21(29-18)5-3-6-22(20)31-14-12-30(13-15-31)11-10-19-4-2-7-23-26(19)34-17-25(33)32(23)16-24(27)28/h2-9,24H,10-17H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT |
Bioorg Med Chem Lett 19: 2338-42 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.056 BindingDB Entry DOI: 10.7270/Q2J967MX |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50413557
(CHEMBL511279)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2cccc3N(CC(F)F)C(=O)COc23)CC1 Show InChI InChI=1S/C26H28F2N4O2/c1-18-8-9-20-21(29-18)5-3-6-22(20)31-14-12-30(13-15-31)11-10-19-4-2-7-23-26(19)34-17-25(33)32(23)16-24(27)28/h2-9,24H,10-17H2,1H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT |
Bioorg Med Chem Lett 19: 2338-42 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.056 BindingDB Entry DOI: 10.7270/Q2J967MX |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human)) | BDBM50413557
(CHEMBL511279)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2cccc3N(CC(F)F)C(=O)COc23)CC1 Show InChI InChI=1S/C26H28F2N4O2/c1-18-8-9-20-21(29-18)5-3-6-22(20)31-14-12-30(13-15-31)11-10-19-4-2-7-23-26(19)34-17-25(33)32(23)16-24(27)28/h2-9,24H,10-17H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 15.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT |
Bioorg Med Chem Lett 19: 2338-42 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.056 BindingDB Entry DOI: 10.7270/Q2J967MX |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50413557
(CHEMBL511279)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2cccc3N(CC(F)F)C(=O)COc23)CC1 Show InChI InChI=1S/C26H28F2N4O2/c1-18-8-9-20-21(29-18)5-3-6-22(20)31-14-12-30(13-15-31)11-10-19-4-2-7-23-26(19)34-17-25(33)32(23)16-24(27)28/h2-9,24H,10-17H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 63.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Displacement of [3H]citalopram human SerT receptor expressed in LLCPK cells |
Bioorg Med Chem Lett 19: 2338-42 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.056 BindingDB Entry DOI: 10.7270/Q2J967MX |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50413557
(CHEMBL511279)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2cccc3N(CC(F)F)C(=O)COc23)CC1 Show InChI InChI=1S/C26H28F2N4O2/c1-18-8-9-20-21(29-18)5-3-6-22(20)31-14-12-30(13-15-31)11-10-19-4-2-7-23-26(19)34-17-25(33)32(23)16-24(27)28/h2-9,24H,10-17H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Displacement of [3H]dofetilide human ERG expressed in CHO cells |
Bioorg Med Chem Lett 19: 2338-42 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.056 BindingDB Entry DOI: 10.7270/Q2J967MX |
More data for this Ligand-Target Pair | |