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BDBM50414095 CHEMBL542007

SMILES: Nc1cc2OC\C=C\CCOc3cncc(NC(=O)Nc2cc1Cl)n3

InChI Key: InChIKey=DSUIEFJZFWCWOF-OWOJBTEDSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50414095   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50414095
PNG
(CHEMBL542007)
Show SMILES Nc1cc2OC\C=C\CCOc3cncc(NC(=O)Nc2cc1Cl)n3 |t:6|
Show InChI InChI=1S/C16H16ClN5O3/c17-10-6-12-13(7-11(10)18)24-4-2-1-3-5-25-15-9-19-8-14(21-15)22-16(23)20-12/h1-2,6-9H,3-5,18H2,(H2,20,21,22,23)/b2-1+
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Chk1


J Med Chem 52: 3159-65 (2009)


Article DOI: 10.1021/jm801444x
BindingDB Entry DOI: 10.7270/Q2FF3TM8
More data for this
Ligand-Target Pair