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BDBM50414282 CHEMBL551301

SMILES: OCCCNc1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1

InChI Key: InChIKey=RSAYOFQTMTVUIZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50414282   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM50414282
PNG
(CHEMBL551301)
Show SMILES OCCCNc1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1 |TLB:15:14:17.16.21:19,21:16:23:20.19.22,21:20:23:17.16.15,13:14:17.16.21:19,THB:15:16:19:23.14.22,22:14:17:21.20.19,22:20:17:23.15.14,13:14:17:21.20.19|
Show InChI InChI=1S/C24H31N3O2/c28-8-2-7-25-22-6-5-19-20(26-22)3-1-4-21(19)27-23(29)15-24-12-16-9-17(13-24)11-18(10-16)14-24/h1,3-6,16-18,28H,2,7-15H2,(H,25,26)(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.94n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptake

J Med Chem 52: 3123-41 (2009)


Article DOI: 10.1021/jm801528x
BindingDB Entry DOI: 10.7270/Q2251KDR
More data for this
Ligand-Target Pair