BDBM50414339 CHEMBL180397

SMILES: CC(C)(CC1=N[C@@H]([C@@H](N1)c1ccccc1)c1ccccc1)c1ccccc1

InChI Key: InChIKey=ABAFZIKNWHPYOU-PSWAGMNNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50414339   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50414339 (CHEMBL180397) Show SMILES CC(C)(CC1=N[C@@H]([C@@H](N1)c1ccccc1)c1ccccc1)c1ccccc1 |t:4| Show InChI InChI=1S/C25H26N2/c1-25(2,21-16-10-5-11-17-21)18-22-26-23(19-12-6-3-7-13-19)24(27-22)20-14-8-4-9-15-20/h3-17,23-24H,18H2,1-2H3,(H,26,27)/t23-,24+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human P2X7 receptor expressed in human U373 cells assessed as inhibition of BzATP-induced Yo-Pro uptake				J Med Chem 52: 3123-41 (2009) Article DOI: 10.1021/jm801528x BindingDB Entry DOI: 10.7270/Q2251KDR
					More data for this Ligand-Target Pair