BDBM50415421 CHEMBL603112

SMILES: CCc1onc(c1C(=O)N(C)c1ccc(Cl)cc1)-c1ccccc1Cl

InChI Key: InChIKey=MRHVWTRKXAGDTN-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50415421   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G-protein coupled bile acid receptor 1 (Homo sapiens (Human))	BDBM50415421 (CHEMBL603112) Show SMILES CCc1onc(c1C(=O)N(C)c1ccc(Cl)cc1)-c1ccccc1Cl Show InChI InChI=1S/C19H16Cl2N2O2/c1-3-16-17(18(22-25-16)14-6-4-5-7-15(14)21)19(24)23(2)13-10-8-12(20)9-11-13/h4-11H,3H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.98	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase rep...				Bioorg Med Chem Lett 20: 1363-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.003 BindingDB Entry DOI: 10.7270/Q2028SS5
					More data for this Ligand-Target Pair