BDBM50415794 CHEMBL1093602::GSK-325971A

SMILES: CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C

InChI Key: InChIKey=XLMANSLWCIMZAE-UHFFFAOYSA-N

Data: 4 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50415794   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50415794 (CHEMBL1093602 | GSK-325971A) Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Medicines Research Centre Curated by ChEMBL					Assay Description Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...				Bioorg Med Chem Lett 20: 2340-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.133 BindingDB Entry DOI: 10.7270/Q2SF2XDJ
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50415794 (CHEMBL1093602 | GSK-325971A) Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>6.31E+3	n/a	n/a	n/a	n/a
Medicines Research Centre Curated by ChEMBL					Assay Description Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as renilla luciferase transactivation activity				Bioorg Med Chem Lett 20: 2340-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.133 BindingDB Entry DOI: 10.7270/Q2SF2XDJ
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50415794 (CHEMBL1093602 | GSK-325971A) Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Medicines Research Centre Curated by ChEMBL					Assay Description Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells assessed as inhibition of aldosterone-induced eff...				Bioorg Med Chem Lett 20: 2340-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.133 BindingDB Entry DOI: 10.7270/Q2SF2XDJ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50415794 (CHEMBL1093602 | GSK-325971A) Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medicines Research Centre Curated by ChEMBL					Assay Description Inhibition of human PDE4B by ATP-luciferace luminescence assay				Bioorg Med Chem Lett 20: 2340-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.133 BindingDB Entry DOI: 10.7270/Q2SF2XDJ
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50415794 (CHEMBL1093602 | GSK-325971A) Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medicines Research Centre Curated by ChEMBL					Assay Description Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells assessed as inhibition of progesterone-induced effec...				Bioorg Med Chem Lett 20: 2340-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.133 BindingDB Entry DOI: 10.7270/Q2SF2XDJ
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50415794 (CHEMBL1093602 | GSK-325971A) Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Medicines Research Centre Curated by ChEMBL					Assay Description Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells				Bioorg Med Chem Lett 20: 2340-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.133 BindingDB Entry DOI: 10.7270/Q2SF2XDJ
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50415794 (CHEMBL1093602 | GSK-325971A) Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Medicines Research Centre Curated by ChEMBL					Assay Description Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells				Bioorg Med Chem Lett 20: 2340-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.133 BindingDB Entry DOI: 10.7270/Q2SF2XDJ
					More data for this Ligand-Target Pair