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SMILES: COc1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2OC)cc1

InChI Key: InChIKey=IBWPSCVRBAUJRW-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50415805   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415805
PNG
(CHEMBL1094034)
Show SMILES COc1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2OC)cc1
Show InChI InChI=1S/C18H20N4O3/c1-11-15-16(25-4)14(10-19-17(15)22(2)21-11)18(23)20-9-12-5-7-13(24-3)8-6-12/h5-8,10H,9H2,1-4H3,(H,20,23)
PDB

KEGG

UniProtKB/SwissProt

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DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair