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SMILES: Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(Cc4ccccn4)nc(C)c3c2Cl)cc1

InChI Key: InChIKey=NNKFXEHLEOZRMZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50415808   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415808
PNG
(CHEMBL1091054)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(Cc4ccccn4)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C26H23ClN6O2/c1-15-23-24(27)21(13-29-25(23)33(31-15)14-20-6-4-5-11-28-20)26(34)30-12-18-7-9-19(10-8-18)22-16(2)32-35-17(22)3/h4-11,13H,12,14H2,1-3H3,(H,30,34)
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Similars
Article
PubMed
n/an/a 251n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair