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SMILES: Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(Cc4ccccc4)ncc3c2Cl)cc1

InChI Key: InChIKey=BZHBYFSQXYPLSW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50415809   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415809
PNG
(CHEMBL1091439)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(Cc4ccccc4)ncc3c2Cl)cc1
Show InChI InChI=1S/C26H22ClN5O2/c1-16-23(17(2)34-31-16)20-10-8-18(9-11-20)12-29-26(33)22-13-28-25-21(24(22)27)14-30-32(25)15-19-6-4-3-5-7-19/h3-11,13-14H,12,15H2,1-2H3,(H,29,33)
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Article
PubMed
n/an/a 316n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair