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BDBM50416406 CHEMBL1210518

SMILES: COc1ccc(Cc2cc(nn(CC(=O)NC3Cc4ccccc4C3)c2=O)C2CCCCC2)cn1

InChI Key: InChIKey=PCPKPOMBIYZDJK-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50416406   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM50416406
PNG
(CHEMBL1210518)
Show SMILES COc1ccc(Cc2cc(nn(CC(=O)NC3Cc4ccccc4C3)c2=O)C2CCCCC2)cn1
Show InChI InChI=1S/C28H32N4O3/c1-35-27-12-11-19(17-29-27)13-23-16-25(20-7-3-2-4-8-20)31-32(28(23)34)18-26(33)30-24-14-21-9-5-6-10-22(21)15-24/h5-6,9-12,16-17,20,24H,2-4,7-8,13-15,18H2,1H3,(H,30,33)
PDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assay

Bioorg Med Chem Lett 20: 4561-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.014
BindingDB Entry DOI: 10.7270/Q2959JSG
More data for this
Ligand-Target Pair