BDBM50416577 CHEMBL1081471

SMILES: Cc1ccc(o1)C1Nc2cc(C)c(C)cc2-n2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1

InChI Key: InChIKey=GERAFLWFPBDYKU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50416577   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50416577 (CHEMBL1081471) Show SMILES Cc1ccc(o1)C1Nc2cc(C)c(C)cc2-n2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1 Show InChI InChI=1S/C28H26N4O3/c1-15-13-19-20(14-16(15)2)32-24(18-9-7-6-8-10-18)22-25(30(4)28(34)31(5)27(22)33)26(32)23(29-19)21-12-11-17(3)35-21/h6-14,23,29H,1-5H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human CFTR expressed in rat FRT cells coexpressing halide indicator YFP-H148Q assessed as inhibition of halide influx preincubated for ...				J Med Chem 52: 6447-55 (2009) Article DOI: 10.1021/jm9009873 BindingDB Entry DOI: 10.7270/Q28W3DHW
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