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BDBM50417263 CHEMBL1271707

SMILES: CN1[C@@H](CN(C1=O)c1cccc(C)n1)C(=O)NCc1cccc(c1Cl)C(F)(F)F

InChI Key: InChIKey=HJCLDZGYOWYDHK-AWEZNQCLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50417263   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM50417263
PNG
(CHEMBL1271707)
Show SMILES CN1[C@@H](CN(C1=O)c1cccc(C)n1)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C19H18ClF3N4O2/c1-11-5-3-8-15(25-11)27-10-14(26(2)18(27)29)17(28)24-9-12-6-4-7-13(16(12)20)19(21,22)23/h3-8,14H,9-10H2,1-2H3,(H,24,28)/t14-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay

Bioorg Med Chem Lett 20: 6370-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.101
BindingDB Entry DOI: 10.7270/Q2NC62GP
More data for this
Ligand-Target Pair