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SMILES: CCN(Cc1nc(C)no1)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C

InChI Key: InChIKey=MFLCCPMKMSCQMJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50417500   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50417500
PNG
(CHEMBL1287877)
Show SMILES CCN(Cc1nc(C)no1)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C |(18.29,-22.05,;16.95,-21.3,;15.64,-22.08,;14.29,-21.33,;13.03,-22.21,;11.57,-21.7,;10.65,-22.92,;9.11,-22.88,;11.52,-24.19,;13,-23.75,;15.65,-23.62,;14.32,-24.41,;14.34,-25.95,;13.02,-26.74,;15.69,-26.7,;17.01,-25.91,;18.48,-26.37,;19.37,-25.12,;20.91,-25.1,;18.45,-23.89,;17,-24.38,;19.19,-27.74,;18.37,-29.04,;19.07,-30.39,;20.61,-30.47,;21.31,-31.83,;22.86,-31.91,;21.44,-29.18,;20.73,-27.81,;21.56,-26.51,)|
Show InChI InChI=1S/C22H26N6O2/c1-7-27(12-19-24-16(5)26-30-19)20-11-14(3)23-22-21(15(4)25-28(20)22)18-9-8-17(29-6)10-13(18)2/h8-11H,7,12H2,1-6H3
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MMDB

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Article
PubMed
 5.01n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor

Bioorg Med Chem Lett 20: 7259-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.095
BindingDB Entry DOI: 10.7270/Q2736S5V
More data for this
Ligand-Target Pair