null

SMILES: COc1ccc(-c2c(C)nn3c(NC(C)Cc4nnc(C)o4)cc(C)nc23)c(C)c1

InChI Key: InChIKey=AAWLWIAKLNIQGZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50417508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50417508 (CHEMBL1287997) Show SMILES COc1ccc(-c2c(C)nn3c(NC(C)Cc4nnc(C)o4)cc(C)nc23)c(C)c1 |(24.76,-42.57,;23.22,-42.6,;22.42,-41.28,;20.88,-41.31,;20.09,-40.02,;20.82,-38.66,;20.02,-37.34,;20.93,-36.11,;22.47,-36.11,;20.03,-34.86,;18.57,-35.32,;17.24,-34.55,;17.25,-33.01,;15.92,-32.23,;15.9,-30.7,;14.58,-33,;13.35,-32.08,;13.37,-30.55,;11.91,-30.06,;11,-31.29,;9.46,-31.27,;11.88,-32.54,;15.89,-35.31,;15.89,-36.86,;14.55,-37.62,;17.22,-37.63,;18.56,-36.86,;22.36,-38.62,;23.1,-37.27,;23.16,-39.95,)| Show InChI InChI=1S/C22H26N6O2/c1-12-9-17(29-6)7-8-18(12)21-15(4)27-28-19(10-13(2)24-22(21)28)23-14(3)11-20-26-25-16(5)30-20/h7-10,14,23H,11H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	251	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Antagonist activity at human recombinant CRF1 receptor				Bioorg Med Chem Lett 20: 7259-64 (2010) Article DOI: 10.1016/j.bmcl.2010.10.095 BindingDB Entry DOI: 10.7270/Q2736S5V
					More data for this Ligand-Target Pair