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SMILES: CCC(Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC)c1nc(C)no1

InChI Key: InChIKey=OVEINYPAMNLCHO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50417511   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50417511
PNG
(CHEMBL1288058)
Show SMILES CCC(Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC)c1nc(C)no1 |(13.38,-27.25,;14.71,-28.02,;14.71,-29.55,;16.04,-30.32,;16.04,-31.86,;14.7,-32.64,;14.7,-34.18,;13.37,-34.95,;16.04,-34.94,;17.37,-34.18,;18.83,-34.66,;19.74,-33.41,;21.28,-33.41,;18.83,-32.16,;17.37,-32.64,;19.55,-36.02,;18.73,-37.32,;19.45,-38.68,;20.99,-38.74,;21.72,-40.1,;20.9,-41.41,;21.81,-37.42,;21.09,-36.06,;21.9,-34.75,;23.43,-34.8,;13.46,-30.44,;12.01,-29.95,;11.09,-31.18,;9.56,-31.16,;11.98,-32.43,;13.44,-31.98,)|
Show InChI InChI=1S/C22H26N6O3/c1-7-17(22-24-14(4)27-31-22)25-19-10-12(2)23-21-20(13(3)26-28(19)21)16-9-8-15(29-5)11-18(16)30-6/h8-11,17,25H,7H2,1-6H3
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MMDB

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Article
PubMed
 50.1n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor

Bioorg Med Chem Lett 20: 7259-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.095
BindingDB Entry DOI: 10.7270/Q2736S5V
More data for this
Ligand-Target Pair