BDBM50417512 CHEMBL1287878

SMILES: COc1ccc(-c2c(C)nn3c(NC(C)c4nc(C)no4)cc(C)nc23)c(C)c1

InChI Key: InChIKey=OHUCVTVUOWVHLG-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50417512   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50417512 (CHEMBL1287878) Show SMILES COc1ccc(-c2c(C)nn3c(NC(C)c4nc(C)no4)cc(C)nc23)c(C)c1 |(24.98,-32.53,;23.44,-32.51,;22.69,-31.16,;21.15,-31.13,;20.4,-29.81,;21.19,-28.48,;20.43,-27.14,;21.39,-25.94,;22.92,-25.99,;20.53,-24.65,;19.05,-25.07,;17.75,-24.25,;17.81,-22.71,;16.5,-21.89,;16.55,-20.36,;15.25,-22.79,;13.79,-22.31,;12.88,-23.53,;11.34,-23.53,;13.77,-24.79,;15.25,-24.33,;16.37,-24.97,;16.32,-26.51,;14.96,-27.23,;17.63,-27.33,;18.99,-26.61,;22.73,-28.5,;23.51,-27.18,;23.48,-29.85,)| Show InChI InChI=1S/C21H24N6O2/c1-11-9-16(28-6)7-8-17(11)19-13(3)25-27-18(10-12(2)22-20(19)27)23-14(4)21-24-15(5)26-29-21/h7-10,14,23H,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	25.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Antagonist activity at human recombinant CRF1 receptor				Bioorg Med Chem Lett 20: 7259-64 (2010) Article DOI: 10.1016/j.bmcl.2010.10.095 BindingDB Entry DOI: 10.7270/Q2736S5V
					More data for this Ligand-Target Pair