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SMILES: FC(F)(F)c1ccccc1C(=O)OCC1CCCN(C1)C(=O)CCc1ccccc1

InChI Key: InChIKey=OCFXPYWXJKNERT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50419816   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuronal acetylcholine receptor subunit alpha-4/beta-2


(Homo sapiens (Human))		BDBM50419816
PNG
(CHEMBL1950637)
Show SMILES FC(F)(F)c1ccccc1C(=O)OCC1CCCN(C1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C23H24F3NO3/c24-23(25,26)20-11-5-4-10-19(20)22(29)30-16-18-9-6-14-27(15-18)21(28)13-12-17-7-2-1-3-8-17/h1-5,7-8,10-11,18H,6,9,12-16H2
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Similars
Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



The Ohio State University

Curated by ChEMBL


Assay Description
Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysis

Bioorg Med Chem Lett 22: 1797-813 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.051
BindingDB Entry DOI: 10.7270/Q22Z16S2
More data for this
Ligand-Target Pair