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SMILES: FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H]1C#N

InChI Key: InChIKey=DGVFSCIOHAESNB-KRWDZBQOSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50420655   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50420655
PNG
(CHEMBL2086616)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H]1C#N |r|
Show InChI InChI=1S/C20H16F3N3O2/c21-20(22,23)15-7-3-13(4-8-15)18(27)25-16-9-5-14(6-10-16)19(28)26-11-1-2-17(26)12-24/h3-10,17H,1-2,11H2,(H,25,27)/t17-/m0/s1
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n/an/a 14.3n/an/an/an/an/an/a



Zydus Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC substrate incubated or 30 mins by fluorescence based assay

Bioorg Med Chem Lett 22: 3516-21 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.078
BindingDB Entry DOI: 10.7270/Q2QZ2C77
More data for this
Ligand-Target Pair