BindingDB logo
myBDB logout

null

SMILES: Oc1c(ccc2cccnc12)C(Nc1cccnc1)c1ccsc1

InChI Key: InChIKey=KSWFNFIKRRTNCX-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50420776   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM50420776
PNG
(CHEMBL2087791)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1cccnc1)c1ccsc1
Show InChI InChI=1S/C19H15N3OS/c23-19-16(6-5-13-3-1-9-21-18(13)19)17(14-7-10-24-12-14)22-15-4-2-8-20-11-15/h1-12,17,22-23H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of human 6x-His tagged wild type BRAF expressed in Sf9 cells by ELISA based kinase assay

J Med Chem 55: 5220-30 (2012)


Article DOI: 10.1021/jm3004416
BindingDB Entry DOI: 10.7270/Q2ZC8451
More data for this
Ligand-Target Pair