null

SMILES: COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CCOCC3)CC3(CC3)C#N)c(SC)nn12

InChI Key: InChIKey=BQNYNQOCMRKPFE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50420934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420934 (CHEMBL2087798) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CCOCC3)CC3(CC3)C#N)c(SC)nn12 |(2.83,-9,;2.85,-7.46,;1.52,-6.68,;1.53,-5.14,;2.87,-4.38,;2.89,-2.84,;4.23,-2.09,;5.56,-2.87,;1.56,-2.06,;.22,-2.82,;-1.11,-2.04,;-2.45,-2.8,;.21,-4.36,;1.58,-.52,;2.92,.23,;2.93,1.77,;1.6,2.56,;.26,1.8,;-1.2,2.29,;-1.8,4.2,;-3.3,4.53,;-3.69,6.02,;-5.17,6.43,;-5.56,7.93,;-4.46,9,;-2.97,8.59,;-2.59,7.1,;-.76,5.33,;.8,5.32,;1.03,3.8,;2.24,4.77,;1.06,6.84,;1.31,8.36,;-2.11,1.05,;-3.65,1.06,;-4.41,2.41,;-1.22,-.2,;.25,.26,)| Show InChI InChI=1S/C29H36N4O4S/c1-34-17-21-14-24(35-2)26(25(15-21)36-3)22-6-5-7-23-27(28(38-4)31-33(22)23)32(19-29(18-30)10-11-29)16-20-8-12-37-13-9-20/h5-7,14-15,20H,8-13,16-17,19H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	194	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair