BDBM50420968 CHEMBL2088259

SMILES: COc1cc(CCc2cc(Nc3ccnc(NCc4ccccn4)n3)[nH]n2)cc(OC)c1

InChI Key: InChIKey=OGJAKSRIKBDGTD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50420968   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50420968 (CHEMBL2088259) Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4ccccn4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C23H25N7O2/c1-31-19-11-16(12-20(14-19)32-2)6-7-17-13-22(30-29-17)27-21-8-10-25-23(28-21)26-15-18-5-3-4-9-24-18/h3-5,8-14H,6-7,15H2,1-2H3,(H3,25,26,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	398	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility...				J Med Chem 55: 5003-12 (2012) Article DOI: 10.1021/jm3004043 BindingDB Entry DOI: 10.7270/Q25X2B62
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50420968 (CHEMBL2088259) Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4ccccn4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C23H25N7O2/c1-31-19-11-16(12-20(14-19)32-2)6-7-17-13-22(30-29-17)27-21-8-10-25-23(28-21)26-15-18-5-3-4-9-24-18/h3-5,8-14H,6-7,15H2,1-2H3,(H3,25,26,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N terminal His6-tagged human IGF1R (959 to end) expressed in baculovirus infected Sf21 cells after 80 mins by caliper mobil...				J Med Chem 55: 5003-12 (2012) Article DOI: 10.1021/jm3004043 BindingDB Entry DOI: 10.7270/Q25X2B62
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50420968 (CHEMBL2088259) Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4ccccn4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C23H25N7O2/c1-31-19-11-16(12-20(14-19)32-2)6-7-17-13-22(30-29-17)27-21-8-10-25-23(28-21)26-15-18-5-3-4-9-24-18/h3-5,8-14H,6-7,15H2,1-2H3,(H3,25,26,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.01	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili...				J Med Chem 55: 5003-12 (2012) Article DOI: 10.1021/jm3004043 BindingDB Entry DOI: 10.7270/Q25X2B62
					More data for this Ligand-Target Pair