BDBM50420978 8-Phenoxymethylcaffeine (8a)::CHEMBL2088299
SMILES: Cn1c(COc2ccccc2)nc2n(C)c(=O)n(C)c(=O)c12
InChI Key: InChIKey=ZMYAPXMDMKEKHX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Adenosine Receptors A2a (A2a) (Rattus norvegicus (rat)) | BDBM50420978 (8-Phenoxymethylcaffeine (8a) | CHEMBL2088299) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University, Private Bag X6001, Potchefstroom 2520, South Africa | Bioorg Chem 49: 49-58 (2013) Article DOI: 10.1016/j.bioorg.2013.06.006 BindingDB Entry DOI: 10.7270/Q21V5CM2 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine Receptors A2a (A2a) (Rattus norvegicus (rat)) | BDBM50420978 (8-Phenoxymethylcaffeine (8a) | CHEMBL2088299) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University Curated by ChEMBL | Assay Description Displacement of [3H]-NECA from Adenosine A2A receptor in Sprague-Dawley rat striatal membranes | Bioorg Med Chem 23: 6641-9 (2015) BindingDB Entry DOI: 10.7270/Q2571DTP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Rattus norvegicus (rat)) | BDBM50420978 (8-Phenoxymethylcaffeine (8a) | CHEMBL2088299) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University Curated by ChEMBL | Assay Description Displacement of [3H]-DPCPX from Adenosine A1 receptor in Sprague-Dawley rat whole brain membranes | Bioorg Med Chem 23: 6641-9 (2015) BindingDB Entry DOI: 10.7270/Q2571DTP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor (Rattus norvegicus (rat)) | BDBM50420978 (8-Phenoxymethylcaffeine (8a) | CHEMBL2088299) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. Electronic address: dalenevanderwalt@gmail.com. Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from adenosine receptor A1 in rat brain membrane in presence of GTP by GTP shift assay | Eur J Med Chem 125: 652-656 (2017) Article DOI: 10.1016/j.ejmech.2016.09.072 BindingDB Entry DOI: 10.7270/Q2QV3PZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM50420978 (8-Phenoxymethylcaffeine (8a) | CHEMBL2088299) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected insect cells using kynuramine as substrate after 20 mins by horseradish perox... | Bioorg Med Chem 20: 4336-47 (2012) Article DOI: 10.1016/j.bmc.2012.05.048 BindingDB Entry DOI: 10.7270/Q2251KGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50420978 (8-Phenoxymethylcaffeine (8a) | CHEMBL2088299) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-B expressed in baculovirus infected insect cells using kynuramine as substrate after 20 mins by horseradish perox... | Bioorg Med Chem 20: 4336-47 (2012) Article DOI: 10.1016/j.bmc.2012.05.048 BindingDB Entry DOI: 10.7270/Q2251KGN | |||||||||||
More data for this Ligand-Target Pair |